The secret in situ life of the protein corona

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Xiaochen has developed a “lock on” spectroscopy for measuring the protein corona on freely diffusing single nanoparticles in situ. The data showed that the “full corona”, comprised of the tightly bound “hard corona” and weakly bound “soft corona”, contains twice as many proteins as ex situ measured hard corona. Therefore, when nanoparticles are removed from the biological fluid for analysis, about half of the proteins that are present in situ are lost. This method shows how critical it is the characterize the nano-bio interface in the native biological solution!

This work has been selected as a “Hot Paper” and will be featured on the back inside cover of an upcoming issue of Angewandte Chemie Int. Ed.. Way to go, Xiaochen! #hotpapersummer

Link to paper: https://onlinelibrary.wiley.com/doi/10.1002/anie.202105741

Cover link: https://onlinelibrary.wiley.com/doi/10.1002/anie.202107758