Cholesterol analogues increase delivery efficiency of lipid nanoparticles
Our collaborators in the Sahay lab (sahaylab.org) have recently reported that naturally occurring cholesterol analogues can increase the delivery efficiency of lipid nanoparticles (LNPs)! Way to go Gaurav and team! Josie and Shangguo applied 3D-DyPLoT to differentiate the intracellular trafficking behavior of different LNP constructs, showing that increased delivery efficiency correlated with increased linear directed motion of individual LNPs in live cells.
Link: www.nature.com/articles/s41467-020-14527-2
